KMID : 0361120060200020261
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Korean Journal of Transplantation 2006 Volume.20 No. 2 p.261 ~ p.264
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A Case of Transplant Glomerulopathy Complicated by Crescent Formation
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Abstract
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Transplant glomerulopathy (TGP) is specified as thickening of capillary wall of glomerulus and clinically presented with proteinuria and progressive graft dysfunction. In contrast, crescent formation represents an extracapillary proliferative glomerular change and is clinically presented with rapidly progressive renal failure. Previously, in transplant kidneys, crescent formation was reported only in anti-GBM disease and ANCAassociated vasculitis. Here we report a case with a very unusual combination of transplant glomerulopathy and crescent formation. Ten years after the renal transplantation the patient was admitted due to proteinuria and progressive azotemia. Although his underlying renal disease was IgA nephropathy, the transplant kidney biopsy revealed typical findings of transplant glomerulopathy without specific immune deposits, but with extensive cellular crescents. Methylprednisolone pulse therapy was not successful, and he was switched to maintenance hemodialysis. (J Korean Soc Transplant 2006;20:261-264)
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KEYWORD
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Transplant glomerulopathy, Kidney transplantation, Crescent formation, Chronic allograft dysfunction
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